Determination of Mexidol in tablets by the method of derivative spectrophotometry

Mexidol (3-hydroxy-6-methyl-2-ethylpyridine succinate) is a drug that exhibits neuroprotective, antihypoxic, anti-ischemic, nootropic, anti-stress and geroprotective effects can suppress or slow down oxidation reactions. Оbjective: to develop selective simple method for assessing the content of mexidol in tablets. Materials methods. The objects study were tablets 0.125 g. Derivative spectrophotometry was used as an analysis method. Results. ability intensively absorb electromagnetic radiation quartz ultraviolet region revealed. This phenomenon due fact analyte molecule contains number chromophore groups: system conjugated aromatic bonds pyridine ring, unpaired electrons at nitrogen atom, enol hydroxyl with In 292 nm, there linear dependence derivatives 2nd order specific absorption coefficient on amount photometric solution (range 2.5-50.0 μg/ml). A calibration graph has been constructed, its equation calculated by least-squares correlation exceeds 0.999. limits detection quantification are 1.25 2.5 µg/ml, respectively. technique characterized necessary reproducibility correctness. values standard deviation relative determination using proposed (n=6; P=0.95) tablet mass 1.16 0.012, respectively, g, 1.32 0.013, Conclusion. developed estimating quantitative g based calculation second-order spectra.